Introduction : Medicap ,the company leader of artificial hair production has recently introduced a new concept of implantable hair unit, based on a thinner fiber size , and more soft and malleable shaft;the consequence from the biocompatibility point of view is a lesser foreign body reaction into the skin, reduced amount of dandruff around the hole of the fiber, and different fibroblastic -macrophage arrangement surrounding the subdermal knot; based on our preliminary experimental ( piglets ) in vivo studies ,we started with a clinical trial as follows:

Materials and methods: A total of 15 patients from different ethnicities were enrolled in the study, including 10 male and 5 female individuals. . The primary edpoint of this study wasthe customer satisfaction in individuals affected by alopecia and treated with Biofibre® 4.0, focusing on scalp hair density and aesthetic perception using a four-level evaluation scale. The secondary objective was to evaluate the rate of implanted hair loss at the one-year follow-up. Biocompatible artificial hair with a diameter of 0.08 mm and a length between 160 and 460 mm (Biofibre® 4.0, Medicap®, Carpi, Italy) were utilized in the present study. The root of each fiber was positioned beneath the scalp, specifically at the level of the galea aponeurotica.

Results: Biocompatibility was excellent, with no reported allergies or significant “foreign body” skin reactions. Analysis based on the primary effectiveness endpoint revealed a mean score of 3.1 on a 4-point grading scale, where 1 = not satisfied (one patient), 2 = somewhat satisfied (two patients), 3 = satisfied (seven patients), and 4 = very satisfied (five patients). Discussion: The implantation of new, thinner artificial hair fibers represents a valid and safe technique. Tolerability has improved due to the increased softness and elasticity of these fibers.

Conclusion: In conclusion, although the sample size is small, the results of this case series confirm the efficacy and safety of the new Biofibre® 4.0 in the treatment of both male and female androgenetic alopecia (AGA), offering a well-tolerated and effective solution for improving aesthetic appearance and psychological well-being.

Dr Beniamino Palmieri has received his PhD in University of Modena during the period of 1972-1974. Currently, he is working as Professor in Modena University. His research interest includes General Surgery, Maxillo-facial, and Plastic Surgery. He is serving as an editorial member of several reputed journals like European Journal Of Cancer, expert reviewers for journals like European Coloproctolgy Journal. He has authored 200 research articles. He is a member of Società Medico-Chirurgica Modena, Società Italiana di Chirurgia, Società Italiana di Chirurgia Plastica, British Surgery Society , American College Of Surgeons.