Age and pregnancy-related hormonal changes affect breast tissue, making simultaneous augmentation-mastopexy a popular corrective procedure. However, despite technical advancements, risks including necrosis, hematoma, implant malposition, and sensory alterations still exist. Understanding and addressing these risks is of utmost importance, as demonstrated in the following case. A 35-year-old woman with grade 3 breast ptosis underwent augmentation-mastopexy with 305 cc silicone implants. Hematoma, skin peeling, and hypoesthesia on the right nipple-areola complex (NAC) that led to partial nipple tip necrosis were noted postoperatively. Following debridement and secretome injection, complete epithelization occurred within a week with enhanced sensory function during 2 month follow up. Non-invasive approaches such as stem cell therapy and its derivatives are highly sought after for managing surgical complications. Abundant in trophic factors, secretome promotes cell proliferation, differentiation, migration, and tissue repair. It is effective in treating skin necrosis by accelerating the wound healing process, and might have potential neuroprotective effects. Several factors may affect NAC viability and sensory function after augmentation- mastopexy. Early intervention, including the use of stem cell-based therapy, may promote tissue regeneration, accelerate healing, and preserve cutaneous sensory function. 

Fellicia Naurah Andryas is the coordinator of Cosmedic, an aesthetic plastic surgery facility and the center of excellence at Bali International Medical Center Siloam Nusa Dua Hospital. She finished medical school in 2023 and completed an internship at the Division of Plastic, Reconstructive, and Aesthetic Surgery at The Clinic Beautylosophy, Jakarta. She is active in plastic surgery research and is hoping to begin residency soon.