Appropriate selection of injectable dermal fillers is substantial in achieving the desired outcome considering their different physiologic effects, tissue interactions, and adverse tissue interactions. Commonly used injectable dermal fillers are derived from Hyaluronic Acid (HA), Calcium Hydroxyl apatite (CaHA), Poly-L-lactic Acid, Polymethylmethacrylate (PMMA), and Autologous fat injections. Precise selection results in optimal cosmetic results. Methods: This systematic review was comprehensively composed from reviewing other existing articles. Result: This study explores the biophysiology, clinical characteristics, tissue interactions, and adverse effects of Hyaluronic Acid (HA), Calcium Hydroxyl apatite (CaHA), Poly-L- lactic Acid, Polymethylmethacrylate (PMMA), and Autologous fat injections as well-known derivatives of injectable dermal fillers. Conclusion: The understanding of each product is beneficial in achieving the desired outcome with minimal adverse effects.

Keyword: Injectable dermal fillers, hyaluronic acid, calcium hydroxyl apatite, poly-l-lactic acid, polymethylmethacrylate, autologous fat injections