Purpose of the study: to systematize information about the role of neurotransmitters as markers of exacerbation of AtD, to assess their indicators in the blood of patients during therapy; identify predictors of a patient achieving a mild form of AtD.

Material and methods: At the first stage of the study, a clinical and laboratory examination of 168 patients with exacerbation of AtD was assessed. At the second stage, among 168 patients, 127 with moderate and severe forms of AtD (SCORAD index > 50) were identified. Predictors of patient achievement in mild 

        

Research results: At the stage of exacerbation of AtD, variable changes in neurotransmitters in the blood serum of patients were revealed. Thus, the average serotonin concentration was 107.8±50.1 ng/ml, median 102.4 [305.0:18.1] ng/ml, reference values (RV) - 36.0-82.0 ng/ml. During the examination of 127 patients with moderate and severe AtD (SCORAD index > 50), a logistic regression model was developed. Serotonin is a significant (p=0.009) predictor of achieving treatment success, along with the SCORAD index and the patient's age.

Conclusion: The data obtained can serve as the basis for the development of complex therapy for AtD, taking into account the study of changes in the concentration of neurotransmitters in the blood serum.

Key words: Atopic dermatitis, microbiome, biomarkers, neurotransmitters