This study aimed to report the main points regarding HIV-induced lipoatrophy and its aesthetic treatments. Methods – Articles published in the last 5 years were reviewed from the PubMed Central, PubMed, and SciELO databases. The references were searched in both Portuguese and English, using the Health Sciences Descriptors (DeCS) and the boolean operators AND and OR: hydroxyapatite OR poly L lactic acid, collagen, injectable AND rejuvenation, calcium hydroxylapatite cosmetic, 3 lipoatrophy AND HIV, lipoatrophy AND poly-L-lactic acid, poly-L lactic acid AND aesthetic treatments. Results – The literature indicates that an increasing number of people are concerned with aesthetics, seeking procedures that offer more youthful and healthy skin. The study shows that collagen biostimulators, such as Calcium Hydroxyapatite (CaHa) and poly-L-lactic acid (PLLA), are effective treatment options for HIV induced lipoatrophy. These substances induce neocollagenesis when injected into the skin layers, through a controlled inflammatory reaction that stimulates fibroblasts to produce new collagen. This process adds volume to the depressed areas caused by lipoatrophy, and also improves the skin's texture, contour, and support. Conclusion – This review highlighted the effectiveness of collagen biostimulators CaHa and PLLA in the treatment of HIV-induced lipoatrophy in relation to antiretroviral therapy (ART). Their efficacy in aesthetic improvement can help professionals avoid adverse events and achieve satisfactory treatment outcomes. Descriptors - Calcium hydroxyapatite, poly-L-lactic acid, biostimulators, HIV, lipoatrophy, aesthetic treatments.

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