Fluorosis is an endemic problem affecting different parts of the country. The endemic fluorosis is observed in many parts of the world where there is excessive amount of fluoride in the drinking water (3-5mg/l). The highest rates of endemicity have been reported in India from Andhra Pradhesh, Haryana, Karnataka, Punjab, Rajasthan and Tamil Nadu. It mainly affects children who are in the age group of 0 to 12 years. Hence we conducted this study among 1505 school children of age 3-15 years to find the existence and severity of dental fluorosis in Dindigul district, one of the endemic areas of fluorosis and subsequently to find the histological signs of dental fluorosis we collected extracted teeth from various dentists across the district and studied them under light microscope and confocal microscope.