Background: The emergence of antibiotic resistance and its side effects have restricted their use in array of prophylactic options in present scenario. Indeed, some new strategies and alternative therapies like herbal medicines and laser therapies have already minimised the use of antibiotic prevent/cure health related issues or oral diseases. Nowadays many authors are trying to prove influence of synbiotics in oral health maintenance so this study was done to check the usage of synbiotics and its benefits in the post extraction tooth socket. 

Aim: The aim of this research is to study the effect of synbiotics supplements on post-surgical complications and oral wound healing after extraction of tooth.

Objectives: To determine the clinical effectiveness and cost-effectiveness of synbiotics over antibiotics and analgesics in post extraction of tooth socket. Materials and Methods: This study is a randomized controlled trial, parallel group, multicentre trial comparing the efficacy of synbiotics in healing of post extraction sockets that was conducted in three centres of Lucknow city-India including BBD dental college of dental sciences. Three groups were made with 80 patients in each group. The primary outcome measures were observed in each group on 3rd day, 5th day and 7th day. 

Results: We could find significant difference between the 3 groups regarding the evaluated parameters. In Table 1 age and gender distribution was observed. Wound related complications like bleeding, swelling and gut flora disturbance at the surgical site was present more in group 2 and group 3 as compared to group 1 which is found statistically significant with p value 0.02, 0.01 and 0.01. In Table 5 the cost analysis during the treatment among the study subjects was noted where statistical significant results were obtained between groups 1 vs group 2; group 1 vs group 3 and group 2 vs group 3 at p ≤ 0.01.

Conclusion: Since this was a novel approach in comparing the post extraction wound healing and as the results showed a definite positive effect by synbiotics. Further studies with a larger sample and different formulation would be recommended to be put into clinical use.