Virtual Conference

Yasmine Ashraf Mohamed Ali

Suez Canal University, Egypt

Title: CXCL13 serum level as a potential biomarker in Vitiligo patients: Correlation with disease activity and severity


Background: Vitiligo is a prevalent autoimmune pigmentary skin disorder, with 0.5-2% global population prevalence. Human follicular T helper cells, dendritic follicular cells, and mesenchymal lymphoid tissue organizer cells all generate the B-cell chemokine CXCL13. CXCL13 and its receptor CXCR5 have been linked to the etiopathogenesis of various autoimmune and inflammatory diseases in latest studies.

Objective: Assessment of serum CXCL13 level in vitiligo patients and its relation to the activity and severity of the disease.

Methods: This case-control study involved 21 vitiligo patients and 21 age and gender matched healthy control. Full history taking, clinical evaluation and assessment of the disease activity and severity were done for all the patients. The CXCL13 serum levels were measured by Enzyme-linked Immunosorbent Assay (ELISA).

Results: The serum CXCL13 levels were significantly higher in vitiligo patients than healthy controls (227.35± 125.70 - 130.58 ± 26.52 ng/L, respectively; p=0.002). There was a significant relationship between CXCL13 and clinical pattern of activity among patients with vitiligo while no correlation with disease activity or severity index scores.

Conclusion: Although CXCL13 was greater in vitiligo patients than in healthy controls, it was unrelated to the activity or severity of the illness. This suggests that CXCL13 may have a role in the immunological pathogenesis of vitiligo.

Keywords: Vitiligo, CXCL13, Autoimmune.


Yasmine Ashraf is an assistant lecturer of dermatology, Faculty of Medicine, Suez Canal University, Egypt. She graduated the Second on her batch in 2018 from the Faculty of Medicine, Suez Canal University.

Yasmine has a Master’s degree in dermatology in the Department of Dermatology, Venereology and Andrology in April 2023, with a general grade of excellence.

She was granted the degree on the 13th of September 2023. Yasmine has participated as a speaker in many national conferences in Dermatology including Sharm derma, ICC, and DMC conferences.

She won the case competition that was at the level of the Arab Republic of Egypt in both ICC and DMC conferences.

Yasmine has been a medical researcher for more than 10 years. She had participated for many years, since she was a student, in the annual conference of the faculty of Medicine, Suez Canal university. Moreover, she worked on 2 research projects based on SEER database by which she submitted her abstracts for the ESMO Asia 2019 congress that were accepted for publication.